Mathematics and Science Center
Library Drive, Room 146
Rochester, MI 48309-4479

Research Programs

OU-WB Institute for Stem Cell and Regenerative Medicine 
Research Program  
Stem Cell Biology . Cancer . Tissue Bioengineering . Regenerative Medicine . Therapeutics

The ISCRM promotes research involving molecular mechanisms that maintain stemness and induce differentiation in stem cells (SCs). SCs provide a renewable resource for tissue engineering and cell therapy. Embryonic stem cells (ESCs) have the greatest potential to self-renew and capacity to differentiate. Cord blood stem cells (CBSCs) and adult stem cells (ASCs) are less potent but are more desirable sources for therapeutic applications. The following are potential areas of stem cell research:

Regulation of stemness and differentiation of ESCs, CBSCs and ASCs
  •       Neurogenesis
  •       Osteogenesis
  •       Chondrogenesis
  •       Myogenesis

Umbilical cord stem cells

  •       Future treatments for developmental and early childhood diseases, including Leukemia,                                  Sickle-cell anemia, and various immunodeficiencies
  •       Use of CBSCs to investigate inherited disorders and disease processes

Induced pluripotent stem (iPS) cell generation, stability, and differentiation

  •       Normal skin cells
  •       Reverse engineering disease pathways

Tissue engineering using human stem cells

  •       Bone and cartilage tissues/structures
  •       Nucleus pulposis in degenerated intervertebral disc
  •       Neural tissues damaged by spinal cord injuries
  •       Fabrication of scaffolds and devices for stem cell collection and tissue regeneration

Restoration of damaged tissue/organ function

  •       Regeneration of pelvic nerve to restore detrusor muscle function in SCIs
  •       Treatment of retinal degeneration using stem cell therapy
  •       Cardiovascular injury and repair
  •       Stem cells for wound healing

Treatment of developmental and age-related degenerative diseases using stem cell therapy

  •       Leukemia
  •       Incontinence
  •       Multiple sclerosis
  •       Parkinson’s disease
  •       Alzheimer’s disease
  •       Diabetes
  •       ALS

Drug discovery and development

  •       miRNA based drugs

Toxicological studies

  •       Development of the NET (New Embryotoxicity) assay for screening drugs and chemicals
  •       Mechanisms of DNA damage and repair in SCs

Rasul Chaudhry, Ph.D., Professor of Molecular Biology,

Co-Director, OU-WB Institute for Stem Cell and Regenerative Medicine   

(248) 370-3350                   Fax: (248) 370-3586