Department of Biological Sciences

Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(location map)
(248) 370-3550
fax: (248) 370-4225

Areas of Research

Many biology majors elect to participate in the research programs of individual faculty members for which they receive course credit (BIO 490). The student must initiate the process by talking to faculty members about their programs. Don't wait for senior year to do this! Other students work one-on-one with faculty members to carry out a library literature search (BIO 405). A paper, based on one of these two options, is required for the B.S. degree.

Biochemistry
Dvir, Arik: Studies of antimicrobial susceptibility and antibiotic tolerance in bacteria. Development of biomedical devices.

Govind, Chhabi: Eukaryotic transcription; recruitment and functional analysis of histone modifying and chromatin remodeling complexes.

Song, Mi Hye: Molecular and genetic mechanisms of centrosome assembly and regulation.
Genetics/
Bioinformatics
Battistuzzi, Fabia : Assessment and development of bioinformatics tools  to address established areas of research and develop new tools to answer the needs arising from a growing community of researchers in evolution.

Jiang, Lan : Mechanisms of biological tube formation in Drosophila tracheal system
 
Lal, Shailesh : Mechanism and regulation of pre-mRNA processing in plants.
 
Song, Mi Hye: Molecular and genetic mechanisms of centrosome assembly and regulation.
 
Wendell, Douglas Genetics of Brassicaceae (the mustard family).
 
Westrick, Randal: Genetics of cardiovascular disease.
Cellular/Molecular
Biology
Banes-Berceli, Amy  : Physiology of hypertension and cell signaling, with a particular focus on JAK/STAT pathway; involvement of JAK/STAT in diabetes mellitus and ANG-induced hypertension.
 
Chaudhry, Rasul : Human embryonic stem cell research - molecular mechanisms of cell differentiation and applications in tissue engineering; molecular genetics of developmental, degradative, and virulent genes
 
Gordon, Sheldon : Cytoskeleton regulation of cell migration and cell cycle progression. Interactions between the basement membrane and cytoskeleton during wound repair.

Govind, Chhabi:  Eukaryotic transcription; recruitment and functional analysis of histone modifying and chromatin remodeling complexes.
 
Hitt, Anne : Cellular and molecular biology of the membrane skeleton of amoeboid cells, membrane protein structure and function.
 
Jiang, Lan : Mechanisms of biological tube formation in Drosophila tracheal system
 
Liu, Zijuan : Molecular mechanisms of metalloid transport in prokaryotes and eukaryotes.
 
Madlambayan, Gerard : Defining the biological mechanisms underlying primary stem cell function in different cancers; applying these findings towards developing clinically relevant drugs and drug delivery strategies to treat these diseases.
 
Song, Mi Hye: Molecular and genetic mechanisms of centrosome assembly and regulation.
Physiology
Banes-Berceli, Amy:  Physiology of hypertension and cell signaling, with a particular focus on JAK/STAT pathway; involvement of JAK/STAT in diabetes mellitus and ANG-induced hypertension.

Blumer-Schuette, Sara: Microbial physiology and genomics relating to life in extreme environments. 

Gordon, Sheldon
: Cytoskeleton regulation of cell migration and cell cycle progression. Interactions between the basement membrane and cytoskeleton during wound repair.

Madlambayan, Gerard
: Defining the biological mechanisms underlying primary stem cell function in different cancers; applying these findings towards developing clinically relevant drugs and drug delivery strategies to treat these diseases.
 
Westrick, Randal : Genetics of cardiovascular disease.
Ecology/
Evolution
Battistuzzi, Fabia : Assessment and development of bioinformatics tools  to address established areas of research and develop new tools to answer the needs arising from a growing community of researchers in evolution.
 
Berven, Keith : Amphibian population biology and evolution of life history patterns.

Hansen, Fay
: Organic farming; Permaculture; Biology of Food.

Jamieson, Mary:  Ecology of plant-insect interactions.

Raffel, Thomas 
: Ecology and evolution of host/parasite interactions.

Tiegs, Scott 
: Stream and river ecology; river restoration; resource subsidies; organic matter decomposition; human impacts to riverine ecosystems; stream-watershed interactions; roles of species in ecosystems.
Immunology/
Microbiology
Blumer-Schuette, SaraMicrobial physiology and genomics relating to life in extreme environments.

Dvir, ArikStudies of antimicrobial susceptibility and antibiotic tolerance in bacteria. Development of biomedical devices.

Liu, Zijuan : Molecular mechanisms of metalloid transport in prokaryotes and eukaryotes.

Walia, Satish
: Molecular microbiology; ecology, epidemiology and mechanism of bacterial antibiotic resistance and virulence genes. Biotechnological approaches for sensitive assay development and engineering of hybrid catabolic pathways for bioremediation of toxic substituted organic chemicals.
Student
Co-Authors

The Department of Biological Sciences is proud to be able to feature our accomplished Graduate and Undergraduate students who have contributed to the research that our labs perform. Below is a list of faculty publications that were coauthored by Oakland University students.

Graduate Students – (G)
Undergraduate Students – (UG)

Amy Banes-Berceli

Bhaskaran, S (G), Zaluski J (UG), Banes-Berceli AKL. (2014). Molecular interactions of serotonin (5-HT) and endothelin-1 (ET-1) in vascular smooth muscle cells - in vitro and ex vivo analyses. Am J Physiol Cell Physiol. 15,306(2):C143-51.

Banes-Berceli, AKL, Al-Azawi H (G), Proctor D (UG), Qu H, Femminineo D (UG), Hill-Pyror C, Webb RC, Brands MB. (2011). Angiotensin II utilizes Janus Kinase 2 in hypertension but not in the physiologic control of blood pressure during low salt intake. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 301: R1169-1176.

Chiasson, VL, Talreja D (G), Young KJ, Chatterjee P, Banes-Berceli AKL, Mitchell BM. (2011). FK506 binding protein 12 deficiency in endothelial and hematopoetic cells decreases regulatory T cells and causes hypertension. Hypertension 57: 1167- 1175.

Brands, MW, Banes-Berceli AKL, Al-Azawi H (G), Allen AJ, Inscho E, Labazi H. (2010). Interleukin-6 knockout prevents angiotensin II hypertension: Role of renal vasoconstriction and JAK2/STAT3 activation. Hypertension 56: 879-884.

Fabia Battistuzzi

Battistuzzi, FU, Brown AC (G). (in press). Rates of evolution under extreme and mesophilic conditions. In Microbial Evolution under Extreme Conditions (ed. Bakermans, C)

Keith Berven

Al-Asuoad, N (G), Anguelov R, Berven K, Shillor M. (2012). Model and Simulations of a Wood Frog Population. Biomath. 1(1):1-6.

Keith Berven & Scott Tiegs

Stephens, JP (G), Berven K, Tiegs S. (2013). Anthropogenic changes to leaf litter input affect the fitness of a larval amphibian. Freshwater Biology 58: 1631-1646.

Stephens, JP (G), Berven K, Tiegs SD. (2013). Leaf-litter impacts the development of larval wood frogs. Freshwater Biology 58: 1631-1646.

Rasul Chaudhry

Dinda S, Chaudhry SR (G), Beeravolu NR (G), McKee C (G), Chaudhry GR. (2014). Inhibition of Embryonic Stem Cell Differentiation by Gold Nanoparticles. J Pharm Pharmacol. 2(4):243-256.

Sheikh, H, Zakharian K, De La Torre RP, Fecek C (G), Vasquez A (G), Chaudhry GR, Svinarich DM, Perez-Cruet M. (2009). In vivo intervertebral disc regeneration using stem cell derived chondroprogenitors. Journal of Neurosurgery: Spine 10: 265.

Chaudhry, GR, Fecek CM (G), Lia M, Wu WC, Cheng M, Vasquez A (G), Pasierb M (G), Trese M. (2009). Fate of ESC derivatives implanted into the vitreous of a slow retinal degenerative mouse model. Stem Cells and Development 18: 247-258.

Fecek, C (G), Yao D, Kaçorri A (G), Vasquez A (G), Iqbal S, Sheikh H, Svinarich DM, Perez-Cruet M, Chaudhry GR. (2008). Chondrogenic derivatives of embryonic stem cells seeded into 3D polycaprolactone scaffolds generated cartilage tissue in vivo. Tissue Engineering Part A 14: 1403-1413.

Sheldon Gordon

Gordon, SR, Wood M (UG). (2009). Soybean agglutinin binding to corneal endothelial cell surfaces disrupts in situ integrity, actin organization and interferes with wound repair. Cell and Tissue Research 335: 551- 563.

Sheldon Gordon & Anne Hitt

Gordon, SR, Climie M (UG), Hitt AL. (2005). 5-Fluorouracil interferes with actin organization, stress fiber formation and cell migration in corneal endothelial cells during wound repair along the natural basement membrane. Cell Motility and the Cytoskeleton 62: 244-258.

Chhabhi Govind

Spain, MM (G), Ansari SA, Pathak R (G), Palumbo MJ, Morse RH, Govind CK. (2014). The RSC complex localizes to coding sequences to regulate Pol II and histone occupancy. Molecular Cell 56, 653-666.

Burugula, BB (G), Jeronimo C, Pathak R (G), Jones JW (G), Robert F, Govind CK. (2014). Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly. Molecular and Cellular Biology 34, 4115-4129.

Spain, MM (G), Govind CK. (2011). A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics. Transcription 2: 78-81.

Anne Hitt

Lahoud, GA (G), Hitt AL, Bryant-Friedrich AC. (2006). Aerobic fate of the C-3’-thymidinyl radical in single-stranded DNA. Chemical Research in Toxicology 19 (12): 1630-1636.

Lan Jiang

Iordanou, E (G), Chandran RR (G), Yang Y, Essak M (UG), Blackstone N (UG), Jiang L. (2014). The Novel Smad Protein Expansion Regulates Receptor Tyrosine Kinase Pathway to Control Drosophila Tracheal Tube Size. Dev Biol. 2014 Sep 1,393(1):93-108.

Chandran, RR (G), Iordanou E (G), Ajja C (UG), Wille M (UG), Jiang L. (2014). Gene expression profiling of Drosophila tracheal fusion cells. Gene Expr Patterns. 2014 Jul,15(2):112-23

Long, SK, Fulkerson E, Breese R, Hernandez G, Davis C, Melton MA, Chandran RR (G), Butler N, Jiang L, Estes P. (2014). A comparison of midline and tracheal gene regulation during Drosophila development. PLoS One. 2014 Jan 20,9(1):e85518.

Zuo, L, Iordanou E (G), Chandran RR (G), Jiang L. (2013). Novel mechanisms of tube-size regulation revealed by the Drosophila trachea. Cell Tissue Research Epub ahead of print July 4, 2013.

Iordanou, E (G), Chandran R (G), Blackstone N (UG), Jiang L. (2011). RNAi interference by dsRNA injection into Drosophila embryos. J Vis Exp. (50). pii: 2477

Shailesh Lal & Fabia Battistuzzi

Rauch, HB (G), Patrick TL (UG), Klusman KM (UG), Battistuzzi FU, Mei W, Brendel VP, Lal SK. (2013). Discovery and expression analysis of alternative splicing events conserved among plant SR proteins. Mol. Biol. Evol.

Shailesh Lal

Barbaglia, A (G), Klusman K (G), Higgins J (UG), Shaw JR, Hannah LC, Lal SK. (2012). Gene capture by Helitron transposons reshuffle the transcriptome of maize. Genetics 190: 965-975.

Lal, SK, Oetjens M (G), Hannah LC. (2009). Helitrons: Enigmatic abductors and mobilizers of host genome sequences. Plant Science 176: 181-186.

Jameson, N (UG), Georgelis N (UG), Fouladbash E (G), Martens S (G), Hannah LC, Lal SK. (2008). Helitron mediated amplification of cytochrome P450 monooxygenase gene in maize. Plant Molecular Biology 67: 295-304.

Lal, SK, Georgelis N (UG), Hannah LC. (2008). Helitrons: their impact on maize genome evolution and diversity. The Maize Handbook: Domestication, Genetics, and Genome, edited by J. Bennetzen and S. Hake. Springer-Verlag, New York.

Gupta, S (G), Ciungu, A (UG), Jameson, N (UG), Lal, SK. (2006). Alternative splicing expression of U1 snRNP 70k gene is evolutionarily conserved between different plant species. DNA SEQ. 17, 254-261.

Clark, AK (G), Kovtunovych G (G), Kandlikar SS (G), Lal SK, Stryker GA. (2005). Cloning and expression analysis of two novel paraflagellar rod domain genes found in Trypanosoma cruzi. Parasitology Research 96, 312-320

Gupta, S (G), Gallavotti A, Stryker GA, Schmidt RA, Lal SK. (2005). A novel class of Helitron-related transposable element in maize contain portions of multiple pseudogenes. Plant Molecular Biology 57, 115-27.)

Gupta, S (G), Wang BB, Stryker GA, Zanetti MA, Lal SK. (2005). Differential splicing and utilization of non-canonical splice sites by two novel arginine/serine-rich (SR) proteins in maize. Biochimica et Biophysica Acta: Gene Expression and Function 1728, 105-114.

Zijuan Liu

Hamdi, M (G), Yoshinaga M, Packianathan C, Qin J, Hallauer J (G), McDermott JR (G), Yang HC, Tsai KJ, Liu Z. (2012). Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio. Toxicology and Applied Pharmacology, 262: 185-193.

Beene, LC (G), Hallauer J (G), Yoshinaga M, Hamdi M (G), Liu Z. (2011). Pentavalent Arsenate Transport by Zebrafish Phosphate Transporter NaPi-IIb1. Zebrafish, 8: 125-131.

Jiang, X, McDermott JR (G), Ajees AA, Rosen BP, Liu Z. (2010). Trivalents arsenicals and glucose use different translocation pathways in mammalian GLUT1. Metallomics 2: 211-219.

McDermott, JR (G), Rosen BP, Liu Z. (2010). Jen1p: A High Affinity Selenite Transporter in Yeast. Molecular Biology of the Cell. 21: 3934-3941.

McDermott, JR (G), Jiang X, Beene LC (G), Rosen BP, Liu Z. (2010). Pentavalent methylated arsenicals are substrates of human AQP9. Biometals. 23: 119-127.

Hamdi M (G), Sanchez MA, Beene LC (G), Liu Q, Landfear SM, Rosen BP, Liu Z. (2009). Arsenic transport by zebrafish aquaglyceroporins. BMC Mol Biol. Nov 25;10:104.

Gerard Madlambayan

Kane, J (G), Krueger SA, Dilworth JT, Torma JT, Wilson GD, Marples B, Madlambayan GJ. (2013). Hematopoietic stem and progenitor cell migration after hypofractionated radiotherapy in a murine model. International Journal of Radiation Oncology Biology Physics 87:1162-1170. doi: 10.1016/j.ijrobp.2013.08.044.

Pezeshkian, B (G), Donnelly C (UG), Tamburo K (UG), Timothy Geddes T, Madlambayan GJ. (2013). Leukemia mediated endothelial cell activation modulates leukemia cell susceptibility to chemotherapy through a positive feedback loop mechanism. PLoS One. 8:e60823. doi: 10.1371/journal.pone.0060823.

Thomas Raffel

Stephens JP (G), Altman KA (G), Berven KA, Tiegs SD, Raffel TR. (2017) Bottom-up and trait-mediated effects of resource quality on amphibian parasitism. J Anim Ecol. 2017 86(2):305-315. 

Stephens JP (G), Stoler AB, Sckrabulis JP (G), Fetzer AJ (UG), Berven KA, Tiegs SD, Raffel TR. (2017) Ontogenetic changes in sensitivity to nutrient limitation of tadpole growth. Oecologia. 183(1):263-273. 

Altman KA (G), Paull SH, Johnson PT, Golembieski MN (UG), Stephens JP (G), LaFonte BE, Raffel TR. (2016) Host and parasite thermal acclimation responses depend on the stage of infection. J Anim Ecol. 85(4):1014-24. 

Stoler AB, Golembieski MN (UG), Stephens JP (G), Raffel TR. (2016) Differential consumption and assimilation of leaf litter by wetland “herbivores”: alternative pathways for decomposition and trophic transfer. Freshwater Science. 35:178-187.

Stephens JP (G), Berven KA, Tiegs SD, Raffel TR. (2015) Ecological stoichiometry quantitatively predicts responses of tadpoles to a food quality gradient. Ecology. 96(8):2070-6.

LaFonte BE, Raffel TR, Monk IN (UG), Johnson PT. (2015) Quantifying larval trematode infections in hosts: A comparison of method validity and implications for infection success. Exp Parasitol. 154:155-62.

Scott Tiegs

Campbell, TB (G), Tiegs SD. (2012). Factors governing the distribution, abundance, and community associations of the invasive round goby (Neogobius melanostomus) in tributaries of the Laurentian Great Lakes. Journal of Great Lakes Research 38: 569-574.

Greiner, HG (G), Kashian D, Tiegs SD. (2012). Impacts of invasive Asian (Amynthas hilgendorfi) and European (Lumbricus rubellus) earthworms in a North American temperate deciduous forest. Biological Invasions 10: 2017-2027.

Nett, JHG (G), Campbell TB (G), Mandrak NE, Tiegs SD. (2012). Detecting invasive Round Goby (Neogobius melanostomus) in wadeable streams: a comparison of gear types. North American Journal of Fisheries Management 32:360-364.

Greiner, HG (G), Stonehouse AMT, Tiegs SD. (2011). Cold tolerance among composting earthworm species to evaluate invasion potential. American Midland Naturalist 166:349-357.

Greiner, HG (G), Costello DM, Tiegs SD. (2010). Allometric estimation of earthworm ash-free dry mass from diameters and lengths of select Megascolecid and Lumbricid species. Pedobiologia 53:247-252.

Satish Walia

Bhutani, N (G), Muraleedharan C (G), Talreja D (G), Rana SW (UG), Walia SK (UG), Kumar A, Walia SK. (in press). Occurrence of multidrug resistant extended spectrum beta lactamase (ESBL) producing bacteria on iceberg lettuce retailed for human consumption. Biomed Research International.

Talreja, D (G), Kaye KS, Yu FS, Walia SK, Kumar A. (2014). Pathogenicity of ocular isolates of Acinetobacter baumannii in a mouse model of endophthalmitis. IOVS, 55(4):2392- 2402.

Talreja, D (G), Muraleedharan C (G), Gunathilaka G, Zhang Y, Kaye KS, Walia SK, Kumar A. (2014). Virulenceproperties of multidrug resistant ocular isolates of Acinetobacter baumannii. Current Eye Research 39(7):695-704.

Walia, S, Rana SW (UG), Maue D (UG), Rana J, Kumar A, Walia SK. (2013). Prevalence of multiple antibiotic-resistant Gram-negative bacteria on bagged, ready-to-eat baby spinach. International Journal of Environmental Health Research 23:108-118.

Satish Walia & Keith Berven

Rana, SW (UG), Kumar A, Walia S, Berven K, Cumper K (G), Walia SK (UG). (2011). Isolation of Tn 1546-like elements in vancomycin resistant Enterococcus faecium isolated from wood frogs: an emerging risk for zoonotic bacterial infections to humans. Journal of Applied Microbiology 110: 35-43.

Doug Wendell

Slankster, EE (G), Chase JM (UG), Jones LM (UG), Wendell D. (2012). DNA-based genetic markers for rapid cycling Brassica rapa (Fast Plants-type) designed for the teaching laboratory. Frontiers in Plant Science 3: 118.

Wendell, DL, Pickard DM, Slankster EE (G), Belz MR (G). (2012). Human genetics with mustard: use of DNA markers for paternity testing in rapid-cycling Brassica rapa (Fast Plants-type). Tested studies for laboratory teaching: proceedings of the 33rd workshop/conference of the Association for Biology Lab Education (ABLE).

Burdzinski, C (UG), Wendell DL. (2007). Mapping the Anthocyaninless (anl) Locus in rapid-cycling Brassica rapa (RBr) to Linkage Group R9. BMC Genetics 8: 64.