408 Meadow Brook Road
Rochester, MI 48309
Oakland University Biosafety
All research, teaching, and studies at Oakland University that involve recombinant DNA, infectious agents, and/or cultured cell lines must be approved by the Institutional Biosafety Committee (IBC) prior to any work performed in the laboratory. Does My Project Require IBC Approval?
Project Application and Revision Via RAM 3.0
- IBC scheduled to meet monthly
- Applications must be submitted 2 weeks prior to scheduled meetings.
- Access to the Research Application Manager: RAM 3.0.
Updates & Announcements
October 2016 is the 3rd annual National Biosafety Month:
National Biosafety Month is a period during which institutions are encouraged to refocus their attention on biosafety policies, practices and procedures.
The theme of this year’s National Biosafety Month is: Evaluation, Collaboration, and Commitment.
- Evaluation: This month Oakland University’s IBC will conduct an IBC Self-Assessment using a matrix developed by NIH.
- Collaborate: The Biosafety Officer and staff frequently collaborate with our fellow state institutions. This month Biosafety staff participated with events hosted by biosafety organizations such as the American Biological Safety Association (ABSA International) and Midwest Area Biosafety Network (MABioN).
- Commitment: Oakland University remains committed to biosafety and providing support to ensure that all operational elements of the biosafety program have the necessary resources.
Exempt rDNA Form:
A new form has been implemented to assist the IBC and applicants in determining if their experiments are exempt. The form is located in the "Overview" tab to the left or you can directly access the form by clicking on Exempt rDNA form.
CRISPR Risk Assessment:
Over the past year there has been a significant number of IBC applications utilizing the powerful gene-editing technology referred to as “CRISPR”. The IBC wants to remind investigators that there are reporting requirements and risks to consider when working with recombinant DNA molecules. All rDNA experiments must be registered with Oakland University’s IBC (exempt or not). Non-exempt experiments must be approved by a convened IBC.
CRISPR technology has a number of risks that the IBC and investigators must consider when approving a project, but there are two applications where the technology poses significant risks.
- CRISPR experiments where the guide RNA can target a human gene, whether it is intentional or as an off-target event.
- “Gene Drive” experiments which increase the spread of genetic elements in a population much quicker than what occurs naturally. Experiments where there is a risk of creating a gene drive system must be carefully evaluated to prevent unintended ecological effects.
For more information on evaluating the risks of your rDNA experiments please click on the Recombinant DNA link on the left column of this page. If you require assistance in evaluating any of the risks involved in your research, please contact Laboratory Compliance Manager, Domenic Luongo at firstname.lastname@example.org .