Department of Biological Sciences

Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(location map)
(248) 370-3550
fax: (248) 370-4225

Jiang

lan jiang

Lan Jiang
Associate Professor, Ph.D.
322 DH
(248) 370-3552
Lab location: 321 DH, 323 DH
Lab phone: (248) 370-3549
jiang23@oakland.edu 

Courses:

  • BIO 309 Biology of the Cell
  • BIO 341 Genetics
  • BIO 491/591 Microscopy

Research : Mechanisms of biological tube formation in Drosophila tracheal system

Biological tube formation is a developmental process required for the formation of the respiratory, vascular and glandular systems of the body. Defects in tube formation result in numerous human diseases including polycystic kidney disease, atherosclerotic heart disease and cancer. The Drosophila trachea system is a complex interconnected tubular network that delivers oxygen to every cell of the body. It is an excellent model system to study the molecular basis of cell migration, cell recognition, cell adhesion and branch fusion during tube formation. Dr. Jiang's work is focused on studying the regulation of tracheal gene expression and how tracheal-expressed genes control the complex cellular behaviors that result in the formation of a continuous tubular network. Current projects in her lab focus on 1) using molecular biology techniques to determine minimal regulatory regions of tracheal-expressed genes to identify potential direct regulators, 2) using expression profiling and cell-separation techniques to isolate tracheal cells and examine gene expression changes at different developmental time-points. 3) using genetics to understand the role that tracheal genes play during the development and function of the tracheal system.

Selected Publications:

Iordanou E, Chandran R, Yang Y, Essak M, Blackstone N, Jiang L. (2014). The novel Smad protein expansion regulates receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Developmental Biology. 393:93-108.

Chandran, RR, Iordanou E, Ajja C, Wille M, Jiang L. (2014). Gene expression profiling of Drosophila tracheal fusion cells. Gene Expression Patterns 15:112-23. 

Long SK, Fulkerson E, Breese R, Hernandez G, Davis C, Melton MA, Chandran RR, Butler N, Jiang L, Estes P (2014). A comparison of midline and tracheal gene regulation during Drosophila development. PLoS One 9:e85518. 

Zhang T, Wang Z, Wang L, Luo N, Jiang L, Liu Z, Wu CF, Dong K. (2013). Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. PLoS Genetics 9(3):e1003327. 

Zuo L, Iordanou E, Chandran RR, Jiang L. (2013). Novel mechanisms of tube-size regulation revealed by the Drosophila trachea. Cell Tissue Research 354:343-54.

Iordanou E., Chandran R., Blackstone N., Jiang L. (2011). RNAi interference by dsRNA injection into Drosophila embryos. Journal of Visualized Experiments 50:2477.

Jiang L., Pearson J.C. and Crews S.T. (2010). Transcriptional regulation of diverse mode of Drosophila tracheal fusion cell expression. Mechanisms of Development 127(5-6): 265-80.

Jiang L., Roger S., Crews ST. (2007). The Drosophila dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesis. Developmental Biology 15:487-499. (Selected as a "Recommended Read by Faculty of 1000")

Jiang L, Crews ST. (2007). Transcriptional specificity of Drosophila dysfusion and the control of tracheal fusion cell gene expression. Journal of Biological Chemistry 28:28659-68. (with cover photo)

Jiang L., Crews ST. (2006). dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion. Molecular and Cellular Biology 26:6547-6556. (with cover photo)

Jiang L., Crews ST. (2003). The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein. Molecular and Cellular Biology 23: 5625-5637. (with cover photo & Selected as a "Recommended Read by Faculty of 1000")